MOTS-c – Research Peptide
MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids and encoded by mitochondrial DNA. It is studied for its role in metabolic regulation, mitochondrial signalling, cellular stress response, inflammatory-response modulation, and energy-balance research.
In research settings, MOTS-c has been investigated for its interaction with AMPK signalling pathways, which are involved in fatty acid oxidation, glucose metabolism, insulin-sensitivity research, and cellular energy regulation. It is also studied for its potential influence on oxidative-stress pathways, inflammatory mediators, mitochondrial function, and nuclear gene-expression regulation.
Due to its connection with mitochondrial biology, metabolic health, glucose-lipid metabolism, cellular stress resistance, and age-related metabolic research, MOTS-c remains a compound of interest in studies exploring obesity-related mechanisms, diabetes research, cardiovascular pathways, and cellular longevity.
At R&R Peptides, MOTS-c is supplied as a lyophilized powder to support maximum stability before reconstitution. It is supplied strictly for laboratory and research purposes only and is not intended for human consumption, medical use, diagnosis, treatment, or prevention of any disease.





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